The effect of the buffer capacity at pH 12 of several DPH formulations on the extent and
lag-time of DPH precipitation upon dilution with Sorensen’s phosphate buffer (SPB) is evaluated
DPH precipitation was evaluated by means of static and dynamic in vitro dilution methods
It is shown that an increase in the formulation buffer capacity decreases substantially the extent of DPH precipitation and increases the lag-time for
precipitation