Hand, foot and mouth disease (HFMD) is a common human syndrome caused by highly contagious intestinal viruses of the picornaviridaefamily typically characterized by a mild fever followed by a rash of flat discolored spots and bumps that may blister, involving the skin of the hands, feet, oral cavity, and occasionally buttocks and genitalia. HFMD mainly affects infants and children, but can occasionally occur in adults.