Humans have been aware of the use of chili peppers and other spicy naturally occurring spices for thousands of years.[1] One of the first commercially available bottled hot sauces appeared in 1807 in Massachusetts.[2] However, of the early brands in the 1800s, few survive to this day. Tabasco sauce is the earliest recognizable brand in the hot sauce industry, appearing in 1868 and becoming synonymous with the term hot sauce.[3] As of 2010, it was the number 13 best-selling condiment in the United States[4] preceded by Frank's RedHot Sauce in number 12 place