Bacteriocins are bacterially produced peptides that are active against other bacteria and against which the producer has a specific immunity mechanism (10, 30). They are produced by all major lineages of bacteria and archaea and constitute a heterogeneous group of peptides with respect to size, structure, mode of action, antimicrobial potency, immunity mechanisms and target cell receptors (21). Here we review the literature with respect to the role of bacteriocin production within complex microbial niches, and in particular in the GI tract, in terms of their impact on the prevalence of the producing strain, as well as on microbial diversity and the survival of pathogens. We conclude with suggestions for future work and the possible ways in which bacteriocins could potentially be applied to enhance health.
Bacteriocins are bacterially produced peptides that are active against other bacteria and against which the producer has a specific immunity mechanism (10, 30). They are produced by all major lineages of bacteria and archaea and constitute a heterogeneous group of peptides with respect to size, structure, mode of action, antimicrobial potency, immunity mechanisms and target cell receptors (21). Here we review the literature with respect to the role of bacteriocin production within complex microbial niches, and in particular in the GI tract, in terms of their impact on the prevalence of the producing strain, as well as on microbial diversity and the survival of pathogens. We conclude with suggestions for future work and the possible ways in which bacteriocins could potentially be applied to enhance health.
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