It should be noted that the peak plasma concentration
of azilsartan achieved after oral administration of the
80 mg maximum approved dose of azilsartan medoxomil
is ∼10 micromolar.51 This is 5 times greater than the peak
plasma concentration of olmesartan that is achieved after
administration of the 40 mg maximum approved dose of
olmesartan medoxomil (∼2 micromolar).52 This could help
further explain the superior BP-lowering action of azilsartan
versus olmesartan