However, synergism
was observed between HELZJ and the antibiotics amikacin and gentamicin, which resulted in decreased
bacterial drug resistance. EHFZJ showed low toxicity in fibroblasts in vitro, while antiparasitic results
against Trypnosoma cruzi, Leishmania braziliensis and Leishmania infantum were not clinically relevant.
Thus, our results indicate that Z. joazeiro Mart. (HELZJ) could be a source of plant-derived natural products
that could lead to the development of promising new antibiotic compounds for infectious diseases.