For example, when an autonomic response is
required, the hypothalamus is the primary response sys tem; when inhibition of a response is
appropriate, the orbitofrontal system participates (LeDoux, 1995). The degree of risk and saliency
of the threat determines which response pathway is more appropriate so that an amygdala-guided
response occurs quickly, and biologi cal survival is assured.
During anxiety states, the subiculum of the hip
pocampus is involved in making comparisons, and the