A hands-on, minds-on inquiry chemistry experiment was developed for use in K–12 schools that enables students to combine the chemicals of their choice and observe the results. The chemistry involved is water based and builds upon acid–base, double displacement, and iodometric detection of starch reactions. Chemicals readily available in the supermarket are mixed in zippered bags thus reducing the risks, cost, and lead time for preparation. In this experiment, students experience a variety of indicators of chemical change including changes in texture, temperature, color, and the evolution of a gas. The “mix and match” design of the experiment provides students with a wealth of data that is used to facilitate students’ abilities to develop a testable question as well as plan and conduct their own experiment. This experimentation is fun and engaging while building students’ science content and process skills.