2.9. Data analysis
Data analysis was performed with OriginPro software (OrginLab).
The effect of treatment was analyzed with either repeatedmeasures
(number of infusions across self-administration
sessions, wheel-turn escape performance, in vivo single-unit recordings,
number of active pokes for initial extinction sessions) or
one-way (total cocaine intake, duration of light delivery, days to
extinction) analysis of variance (ANOVA). Main effects and interactions
were considered statistically significant if p < 0.05. When
appropriate, post hoc analyses and planned comparisons were
performed using Bonferroni-Holm correction for multiple comparisons.
Statistical outliers, indicated by data two standard deviations
beyond the group mean, were excluded from analyses.
Values in graphs are represented as mean ± SEM