Creatine increases anaerobic capacity, aerobic recovery, and protein synthesis. In animal studies, it has
been shown to give positive results on treatment of traumatic brain injury and Lou Gehrig’s disease. Also,
LaVonne Veatch Goodman, M.D. reported in January 2006 that creatine has positive effects on Huntington’s
Disease. It has been reported that creatine is bioavailable in brain and reduces serum.4
After scientists discovered creatine is stored in intramuscular and plays a role in muscular metabolism,
the drug went commercial. Creatine has been used in dietary supplements and has been implemented as
supplements to athletes. Although it is not regulated by the FDA, it is not banned by National Collegiate
Athletic Association or the International Olympic Committee.2
It is widely used among several age group
athletes. A University of Wisconsin Sports Medicine researched in a survey given to high school student
athletes. About 25.3% of students reported using creatine as a supplement. More upper level high school
students reported using creatine as a supplement compared to freshman (50.5% : 10.4%).2
The synthesis of
creatine is shown in Scheme