. Results and discussion
BTX radically and irreversibly affects Nav1.8/b1. Fig. 2A
shows representative current traces in response to voltage
steps. Parts I and IV clearly show that Nav1.8/b1 does not
inactivate in the presence of 10 lM BTX, illustrating that the
inactivation process is severely altered. Fig. 2B shows the
corresponding current–voltage (I–V) relation and Fig. 2C
displays the steady-state activation and inactivation curves.
The voltage-dependence of activation is shifted towards more
hyperpolarised potentials, resulting in the opening of Nav1.8/