Gingerol- Ginger, the rhizome of Z.officinale is
reported to possess antioxidant, anti-inflammatory,
antiseptic and carminative properties.Studies have
shown that ginger inhibits both cyclo-oxygenase and
lipo-oxygenase pathways.The major constituents of
ginger include volatile oils, oleoresin(gingerol),
linoleic acid and trace elements such as magnesium,
phosphorus and potassium. In vitro studies suggest that
gingerol is a potent inhibitor of NO synthesis and also
an effective protector against peroxynitrite mediated
damage.3Another in-vitro study showed it to be
effective in inhibiting production of PGE2 and TNF-a
and COX-2 expression in human synoviocytes by
regulating NF-KB activation and degradation of its
inhibitor IKBa.4