Antioxidants were tested in artichoke extracts and precipitates (in vitro studies). ► Effective antioxidants in in vitro test were tested on cut tissue (in vivo studies). ► PA, CaCl2, CD, and HMP were not effective in in vitro studies. ► AA, CA, and Hexyl damaged artichoke tissue at high concentrations. ► 0.5% Cys extended shelf life of fresh-cut artichokes.