to examine the mutual relationships between sleep and the immune system, two approaches have been generally used. The first is a human volunteers who have been sleep-deprived. It can be seen that the effects on selected immune parameters determined. It is now possible to conclude that sleep deprivation alters immune function and that any immune challenge will eventually alter sleep quality. The objective of the review is to summarize some of the mechanisms implicated in the mutual interaction between sleep and the immune system.