Drug therapy. The most common drugs used in the treatment of gallbladder disease are analgesics, anticholinergics (antismodics), fat-soluble vitamins, and bile salts. Morphine ma initially for pain management. NSAIDs have also been shown to be helpful in pain management. A cholinergics such as atropine and other antispasmodics ma used to relax the smooth muscle and decrease ductal tone.