The empirical results from this study suggest that food price and availability measures play a limited role in the weight outcomes of U.S. adult men and women, in general, although there are some significant effects for certain subpopulations. Fast-food prices are not found to be associated with male or female adult weight in any of the models. Findings show that higher fruit and vegetable prices are related to higher adult female BMI (elasticity of 0.03) but not statistically significantly related to male BMI. In particular, higher fruit and vegetable prices are related to higher BMI among poor women (elasticity of 0.09) and women with children (elasticity 0.04).