the
relationship of sESAM to cardiovascular events might simply reflect
a passive relationship of sESAM to renal function. However, previously
reported hazard ratios for cardiovascular events [25] in the
range of eGFR present in this cohort are appreciably lower than the
hazard ratio associated with escalating sESAM levels in our analysis,
even after adjustment for eGFR. This may suggest an additive
role of sESAM because it reflects an element of cardiovascular risk
imposed by CKD that was not captured by eGFR in this cohort.