Furuse et al. (22) also investigated the effects of two different
levels of MCT on feed intake in rats. They further
examined the capacity of endogenous cholecystokinin (CCK)
to modulate feed intake with MCT. Feed intake of male
Wistar rats fed diets containing CO, MCT or a 1:1 mixture of
CO and MCT was determined every hour for 12 h and then at
2-h intervals for the following 12 h. In a separate trial, Devazepide
(DVZ), a CCK-A receptor antagonist, was injected
intraperitoneally 40 min before feeding and feed intake was
measured at 1, 2, 3 and 6 h postinjection. Feed intake decreased
in a dose-dependent manner with increased concentration
of MCT in the diet and was enhanced 2 h after DVZ
injection. After 3 h, intake of the MCT diet was less than that
of the CO diet. The authors thus concluded that satiety is
affected by carbon chain length in dietary TG sources.