The interaction between cationic amphiphilic drug promazine
hydrochloride (PMZ) with b-cyclodextrin (b-CD) was studied.
It was found that apparent critical micelle concentration
(cmc*
) increases on increasing the b-CD concentration. DGmic
becomes less negative on increasing the b-CD concentration
indicating the decrease in feasibility of micelle formation in presence
of b-CD. Viscosity first increases then decreases on increasing
the PMZ concentration and in the presence of b-CD the
viscosity increment was lower as compared to the pure aqueous
solution of the drug