Diseases of the sinonasal system, specifically chronic rhinosinusitis
(CRS), are often associatedwith pulmonary system
diseases. Asthma sensitive to the ingestion of aspirin may be
associated with nasal polyps. Allergic fungal rhinosinusitis in
the upper airway could be associated with allergic bronchopulmonary
aspergillosis.5 Patients with cystic fibrosis invariably
develop CRS in addition to their debilitating pulmonary
disease. These are attributed to similar mechanisms of inspissated
mucus, impaired mucociliary clearance, and persistent
bacterial infections and inflammation. Moreover, the lungs
and the paranasal sinuses share contact with inhaled pathogens
and include many of the same epithelial properties.6
SPs appear to have an important function in immunologic
and rheological process of the nasal mucosa and support the
therapeutic use of liposomal nasal sprays.7