Bile salts (BS) are bio-surfactants

Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial role in the

digestion and absorption of nutrients. The importance of BS for controlled release and transport of lipid

soluble nutrients and drugs has recently stimulated scientific interest in these physiological compounds. BS

are so-called facial amphiphiles showing a molecular structure that is very distinct from classical surfactants.

This peculiar molecular structure facilitates the formation of dynamic aggregates able to solubilise and

transport lipid soluble compounds. The detergent nature of BS has been studied in the literature, mostly

concentrating on the self-assembly behaviour of BS in solution but also in relation to protein denaturation and

its effect on improving proteolysis. In contrast, the affinity of BS for hydrophobic phases has received less

attention and studies dealing directly with the interfacial behaviour of BS are very limited in the literature.

This is despite the fact that the interfacial activity of BS plays a vital role in fat digestion since it is closely

involved with lypolisis. BS adsorb onto fat droplets and can remove other materials such as proteins,

emulsifiers and lipolysis products from the lipid surface. The unusual surface behaviour of BS is directly

related to their intriguing molecular structure and further knowledge could provide an improved

understanding of lipid digestion. This review aims to combine the new insights gained into the surface

properties of BS and their role in digestion. A better understanding of surface activity of BS would allow

manipulation of physico-chemical and interfacial properties to modulate lipid digestion, improve

bioavailability of lipid soluble nutrients and reduce absorption of saturated fats, cholesterol and trans fats.

ผลลัพธ์ (ไทย) 1:

Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial role in thedigestion and absorption of nutrients. The importance of BS for controlled release and transport of lipidsoluble nutrients and drugs has recently stimulated scientific interest in these physiological compounds. BSare so-called facial amphiphiles showing a molecular structure that is very distinct from classical surfactants.This peculiar molecular structure facilitates the formation of dynamic aggregates able to solubilise andtransport lipid soluble compounds. The detergent nature of BS has been studied in the literature, mostlyconcentrating on the self-assembly behaviour of BS in solution but also in relation to protein denaturation andits effect on improving proteolysis. In contrast, the affinity of BS for hydrophobic phases has received lessattention and studies dealing directly with the interfacial behaviour of BS are very limited in the literature.This is despite the fact that the interfacial activity of BS plays a vital role in fat digestion since it is closelyinvolved with lypolisis. BS adsorb onto fat droplets and can remove other materials such as proteins,emulsifiers and lipolysis products from the lipid surface. The unusual surface behaviour of BS is directlyrelated to their intriguing molecular structure and further knowledge could provide an improvedunderstanding of lipid digestion. This review aims to combine the new insights gained into the surfaceคุณสมบัติของบีและบทบาทของตนในการย่อยอาหาร ของกิจกรรมที่พื้นผิวของบีจะช่วยให้การจัดการคุณสมบัติดิออร์ และแรงการปรับย่อยไขมัน ปรับปรุงดูดซึมสารอาหารละลายไขมัน และลดการดูดซึมของไขมันอิ่มตัว ไขมันคลอเรสเตอรอลและทรานส์