RCTs WITH A PLACEBO CONTROL
Twelve of the 14 placebo-controlled studies found that IV acetaminophen patients had improved analgesia. Ten of the 14 placebo-controlled studies found either a significant reduction in mean opioid consumption or a lower percentage of patients rescuing with IV acetaminophen. One study that had no observed pain difference found that IV acetaminophen patients did need less rescue compared with placebo patients.