Our findings with empagliflozin can be compared with the effects of dapagliflozin in the DAPA-HF trial.5 The current trial was enriched for patients with a markedly reduced ejection fraction and increased levels of natriuretic peptides, as compared with the patients in the DAPA-HF trial (Table S4). Consequently, the incidence of the primary outcome was approximately 40% higher in the current trial than in the DAPA-HF trial. Our trial thus extends the benefits of SGLT2 inhibitors to patients with more advanced but stable heart failure