(RR = 175) laboratory strain isolated from Brazil [40]. Classical biochemical
assays had indicated the involvement of insecticide
detoxification – based resistance mechanisms. Six genes were
highly over-expressed in resistant mosquito larva compared to a
susceptible strain, including three GSTs (GSTI1, GSTO1, GSTX2),
one esterase (CCae3A) and one P450 monooxygenase (CYP6N12)
(Table 2). The role of these genes (if any) in temephos resistance
remains to be established by functional assays.