A comparison of the NOAEL (106 mg TOS/kg bw/day) from the 90-day study with the TMDI
(assessment performed according to the Budget method; Section 4), calculated to be 0.31 mg TOS/kg
bw/day, results in a margin of exposure (MOE) of 345, which is found sufficient in the light of the
conservative interpretation of the effects observed in the 90-day oral toxicity study and the
conservative nature of the exposure estimate.