Converging lines of evidence suggest that progressive cerebral deposition of A B also plays an important role in the pathogenesis and development of AD, as its accumulation may result in a cascade of biochemical events leading to neuronal dysfunction.
is a proteolytic fragment derived from the amyloid precursor protein (APP), a transmembrane glycoprotein that is usually processed by the enzyme - secretase to generate in physiological conditions small and soluble peptides.