General Characteristics
Twenty patients were included. Fourteen (70%) were
men. The median age was 57 (40 –70) years. Table 1 shows
the cohort’s baseline characteristics. Nineteen patients
(95%) were admitted to the ICU due to hypoxemic ARF.
The median duration of ARF before inclusion in the study
was 4 (3– 8) days.
Subjective Assessment and Respiratory Variables
The results of the subjective assessment show a significant
improvement in the 3 variables analyzed with the useof HFNC (Table 2). In the evaluation of respiratory variables,
there were no significant differences between the
baseline values and those at the end of 30 min of face
mask use. However, with HFNC there was a significant
increase in PaO2 and a reduction in respiratory rate (Fig. 2),
without hypercapnia or acidosis. Arterial blood samples
were not obtained from the 4 patients who did not have
arterial catheters. There was no significant change in mean
arterial pressure or heart rate. Once the testing period had
been completed and the patients were asked to choose
which of the 2 oxygen therapy systems they wanted to
continue using, all chose the HFNC.
Adverse Effects
Five patients (25%) reported some mild adverse effects
that may have been related to the HFNC. The most common
(3 patients) was a sensation of cervical-thoracic discomfort
that appeared during the initial period of increasing
flow, and immediately disappeared when flow was
decreased. Another patient said that the gas temperature
was too high. In all the latter cases the effects appeared in
the initial few minutes of the testing period and had completely
disappeared by the end of the testing period. The
other patient who reported an adverse effect had nonspecific
nasal discomfort, and nasal mucosal lesions were detected
during HFNC use. On the other hand, mucosal lesions were
seen before HFNC in another patient, probably related to the
previous use of conventional nasal cannula.
General Characteristics
Twenty patients were included. Fourteen (70%) were
men. The median age was 57 (40 –70) years. Table 1 shows
the cohort’s baseline characteristics. Nineteen patients
(95%) were admitted to the ICU due to hypoxemic ARF.
The median duration of ARF before inclusion in the study
was 4 (3– 8) days.
Subjective Assessment and Respiratory Variables
The results of the subjective assessment show a significant
improvement in the 3 variables analyzed with the useof HFNC (Table 2). In the evaluation of respiratory variables,
there were no significant differences between the
baseline values and those at the end of 30 min of face
mask use. However, with HFNC there was a significant
increase in PaO2 and a reduction in respiratory rate (Fig. 2),
without hypercapnia or acidosis. Arterial blood samples
were not obtained from the 4 patients who did not have
arterial catheters. There was no significant change in mean
arterial pressure or heart rate. Once the testing period had
been completed and the patients were asked to choose
which of the 2 oxygen therapy systems they wanted to
continue using, all chose the HFNC.
Adverse Effects
Five patients (25%) reported some mild adverse effects
that may have been related to the HFNC. The most common
(3 patients) was a sensation of cervical-thoracic discomfort
that appeared during the initial period of increasing
flow, and immediately disappeared when flow was
decreased. Another patient said that the gas temperature
was too high. In all the latter cases the effects appeared in
the initial few minutes of the testing period and had completely
disappeared by the end of the testing period. The
other patient who reported an adverse effect had nonspecific
nasal discomfort, and nasal mucosal lesions were detected
during HFNC use. On the other hand, mucosal lesions were
seen before HFNC in another patient, probably related to the
previous use of conventional nasal cannula.
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General Characteristics
Twenty patients were included. Fourteen (70%) were
men. The median age was 57 (40 –70) years. Table 1 shows
the cohort’s baseline characteristics. Nineteen patients
(95%) were admitted to the ICU due to hypoxemic ARF.
The median duration of ARF before inclusion in the study
was 4 (3– 8) days.
Subjective Assessment and Respiratory Variables
The results of the subjective assessment show a significant
improvement in the 3 variables analyzed with the useof HFNC (Table 2). In the evaluation of respiratory variables,
there were no significant differences between the
baseline values and those at the end of 30 min of face
mask use. However, with HFNC there was a significant
increase in PaO2 and a reduction in respiratory rate (Fig. 2),
without hypercapnia or acidosis. Arterial blood samples
were not obtained from the 4 patients who did not have
arterial catheters. There was no significant change in mean
arterial pressure or heart rate. Once the testing period had
been completed and the patients were asked to choose
which of the 2 oxygen therapy systems they wanted to
continue using, all chose the HFNC.
Adverse Effects
Five patients (25%) reported some mild adverse effects
that may have been related to the HFNC. The most common
(3 patients) was a sensation of cervical-thoracic discomfort
that appeared during the initial period of increasing
flow, and immediately disappeared when flow was
decreased. Another patient said that the gas temperature
was too high. In all the latter cases the effects appeared in
the initial few minutes of the testing period and had completely
disappeared by the end of the testing period. The
other patient who reported an adverse effect had nonspecific
nasal discomfort, and nasal mucosal lesions were detected
during HFNC use. On the other hand, mucosal lesions were
seen before HFNC in another patient, probably related to the
previous use of conventional nasal cannula.
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