Specifically, disembodied
(Cyp302A1; dib), shade (Cyp314A1, shd), and shadow
(Cyp315A1; sad) are all mitochondrial CYPs involved in
the last three steps of 20-hydroxyecdysone (20-HE) synthesis.
Cyp314A1 is the CYP required for the conversion
of ecdysone to its active form, 20-HE [19,23]. The other
three CYPs are divided into two new families CYP362
(Cyp362A1, Cyp362A2) and Cyp363A1, indicating that
these CYPs are not as well conserved and probably have
taken on new roles. A tree of the mitochondrial CYP clan
is available as supplementary material