In this study, biofoam was prepared from cassava starch using compression molding technique. The optimum conditions for biofoam processing were a temperature of 220oC, a pressure of 1000 atm and 4 min-processing time. polypropylene and cotton fiber blended with the latex were used as reinforcing additives were evaluated as a function of Polypropylene : cotton fiber ratio 1:0 3:1 1:1 1:3 and 0:1. In order to improve Physical mechanical and biodegradation properties of the biofoam, The density of the prepared biofoam was in the range 0.2335-0.3297 g/cm3, which was considerable higher than of expanded polystyrene foam. Water resistance test confirmed that the addition Increased of cotton fiber caused the foam to remain in shape after soaking in water for 12 hrs. moreover, contact angle of water and oil, it was found that the water and oil contact angle of foam is smaller than 90° , the foam surface is considered good wetting. Scanning electron microscopy (SEM) revealed that with the addition of additives, the foam showed smoother surface. When increase cotton fiber was added, the foam roughness surface increased as polypropylene fiber content increased. Flexural strength type Three-pointed bending revealed that with the addition of polypropylene and cotton fiber blended with the latex, the hardness of the foam decrease as polypropylene increased. Finally, when increased polypropylene fiber was added. The degradation behavior of the biofoam was investigated by soil burial test.