Other groups have developed whole genome PCR sampling approaches that
amplify targeted or arbitrary segments of the yeast genome resulting in strain-specific
fingerprints. In general whole genome PCR sampling techniques are popular
because of the ease of use, however, the reproducibility of these approaches – which
vary among laboratories, personnel and thermocyclers – is often problematic. One
approach employs primers to amplify repeated regions in the genome such as delta
elements of the Ty transposon, intron splice sites, minisatellites or micro-satellite markers.