3) Clinical Global Impression Scale (CGIS): This is an assessment scale developed by Guy (13). It is used for evaluation by clinician to assess the severity and evolution of disease and efficacy of medications being used. Scale has 3 sub-scales assessing severity, global improvement and severity of adverse effects. Severity sub-scale was used to assess severity of disease in this study. Severity levels at the scale are as follows: 1, normal, not at all ill; 2, borderline mentally ill; 3, mildly ill; 4, moderately ill; 5, markedly ill; 6, severely ill; or 7, extremely ill.