During the past decade, a hyper-butanol-producing strain has
been developed as a result of the application of modern molecular
techniques and genetic manipulation to the solventogenic clostridia
[9]. Experimental and computational engineering efforts
have also led to improved fermentation techniques, downstream
processing, and process integration. All these developments resulted
in a significant increase in biobutanol titer, yield and recovery
[10]. Computer simulation is used to scale up experimental
results and provide meaningful predictions on the performance
and economics of a full scale industrial plant. The number of publications
available regarding ABE process simulation is however
very limited [11–15].