The use of medications as an adjunct to alcoholism treatment is based on the premise that
craving and other manifestations of alcoholism are mediated by neurobiological mechanisms.
Three of the four medications approved in the United States or Europe for treating
alcoholism are reported to reduce craving; these include naltrexone (ReVia™), acamprosate,
and tiapride. The remaining medication, disulfiram (Antabuse®), may also possess some
anticraving activity. Additional medications that have been investigated include ritanserin,
which has not been shown to decrease craving or drinking levels in humans, and
ondansetron, which shows promise for treating early onset alcoholics, who generally respond
poorly to psychosocial treatment alone. Use of anticraving medications in combination (e.g.,
naltrexone plus acamprosate) may enhance their effectiveness. Future studies should address
such issues as optimal dosing regimens and the development of strategies to enhance patient