Although initially effective, sulfonylureas are associated with poor glycemic
durability, weight gain, and hypoglycemia. Dapagliflozin, a selective inhibitor of sodium-glucose
cotransporter 2 (SGLT2), reduces hyperglycemia by increasing urinary glucose excretion independent of insulin and may cause fewer of these adverse effects. We compared the efficacy, safety,
and tolerability of dapagliflozin with the sulfonylurea glipizide in patients with type 2 diabetes
inadequately controlled with metformin monotherapy