VEGF level was down-regulated resulting in the inhibition of
breast cancer angiogenesis. Our pathology diagnosis results also
supported this, which meant that no metastasis was found in rat
organ (data not shown). Expression level of VEGF tightly correlates
with clinical prognosis. In an ovarian carcinoma xenograft model
(HOC22), level of VEGF directly reflects to tumor burden and ascites
volume