The methodological quality of all selected articles was assessed by considering the extent to which blinding was
present; whether consecutive patients were enrolled in the trial; whether groups were equal at baseline; whether
cointervention was adequately described; whether objective definitions of infectious outcomes were employed; the
completeness of follow-up; and whether all patients were properly accounted for in the intention-to-treat analysis. The
author does not state how the papers were assessed for quality, or how many of the reviewers performed the quality
assessment