60% to 86% of the dose is absorbed.
Ibuprofen is highly protein-bound (90% to 99%).
Elimination is through hepatic biotransformation to inactive & metabolites excreted by kidney filtration and secretion.
About 70% of the drug is excreted in the urine
Marked enterohepatic recirculation occurs
In dogs, the elimination half-life is 3.9 to 5.3 hours