Recently, ultra-high-pressure liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) was reported for the simultaneous determination of amphetamine, amphetamine-like stimulants, cocaine and its metabolites, and cannabinoids metabolites in wastewater samples. Despite of fast separation, improved resolution and good LODs
(LODs were0.3 ng/mL for ATS and 3 ng/mL for THCCOOH), aforementioned method required the expensive equipments and high skilled personnel.