The personal glucose meter (PGM) is a successful device for point-of-care testing, which has wide accessibility to the public worldwide due to a great deal of advantages including the portable “pocket” size, cost effectiveness, reliable quantitative results and easy operation . However, the application of this successful portable sensor is still limited in its single target (glucose) and its dynamic range of 10–600 mg/dL or 0.6–33 mM glucose . Recently, different approaches have been developed to expand the application of PGM. For example, Xiang and Lu (2011, 2012a, 2012b, 2013) developed some sensors to monitor a series of nonglucose targets by taking advantage of invertaselabeled functional DNAs and antibodies.