This lack of consistency is in part due to the “biological” nature of NR, which contains as much as 5% of non-isoprene components whose composition could vary upon the clones, season, and tapping system. These non-isoprene components comprise lipids, proteins, carbohydrates and inorganic constituents. Many studies hypothesize that the differences in mechanical properties between NR and SR are in fact due to the presence of these natural ‘impurities’ in NR and the corresponding formations of microstructures at different scales, which enhances the mechanical properties. One envisaged method to ‘break’ the strong links between polymer chains and proteins in the supernatant is to use ultrasonic (US) treatment. The hypothesize show that US treatment may help to break the links between polymer chains and proteins.