(A) Male GFAP-Cre × flBDNF KO mice exhibited an increase in locomotor activity (ambulation), as assessed by a consecutive horizontal beam break, over a 2-hour period (n = 12) (*p = .018). (B) The increased hyperactivity in the male GFAP-Cre × flBDNF KO mice is not due in response to a novel environment as assessed by a locomotor habituation paradigm.