In predictive microbiology, mathematical models are developed
that can quantify the microbial evolution in food products or food
processing environments. The development of a mathematical
model follows the general model building procedure, which
encloses three basic steps (Asprey & Macchietto, 2000; Tarantola,
2005). Initially, relevant a priori knowledge is collected and a set
of independent variables (e.g., physical quantities) is determined
which defines the investigated system (parameterization of the
system). Next, one or more mathematical model structures are
proposed that are able to predict the system’s behavior (forward
modeling). A precondition is that the models are structurally
identifiable, i.e., all model parameters can be identified uniquely. In
the third step, the predictive quality of the models is improved by
adjusting the intrinsic model parameters to the actual measurements
(parameter estimation). Subsequently, the validity of its
structure and parameter estimates is tested against new experimental data.
When the descriptive quality of the model is insufficient, an adaptation of the model structure and/or parameter estimates is needed. As such, model structure selection and parameter estimation are combined in an iterative model building cycle. Finally, a model is obtained that agrees with reality as closely as possible.
In predictive microbiology, mathematical models are developed
that can quantify the microbial evolution in food products or food
processing environments. The development of a mathematical
model follows the general model building procedure, which
encloses three basic steps (Asprey & Macchietto, 2000; Tarantola,
2005). Initially, relevant a priori knowledge is collected and a set
of independent variables (e.g., physical quantities) is determined
which defines the investigated system (parameterization of the
system). Next, one or more mathematical model structures are
proposed that are able to predict the system’s behavior (forward
modeling). A precondition is that the models are structurally
identifiable, i.e., all model parameters can be identified uniquely. In
the third step, the predictive quality of the models is improved by
adjusting the intrinsic model parameters to the actual measurements
(parameter estimation). Subsequently, the validity of its
structure and parameter estimates is tested against new experimental data.
When the descriptive quality of the model is insufficient, an adaptation of the model structure and/or parameter estimates is needed. As such, model structure selection and parameter estimation are combined in an iterative model building cycle. Finally, a model is obtained that agrees with reality as closely as possible.
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