Studies varied widely
in design, populations, control groups and methods. There was a high level of heterogeneity as measured by
I2 statistics for both outcomes examined. The relationship between antidepressant exposure in pregnancy and
adverse birth outcomes did not differ significantly when taking into account drug type (SSRI vs. other or mixed)
or study design (prospective vs. retrospective). There was a significant association between antidepressant
exposure and PTB for different types of control status used (depressed, mixed or nondepressed).