Clinical Implications—Our results indicate nurse-delivered screening and treatment of postpartum women is overwhelmingly supported by this segment of US nursing professionals, and indeed, is already occurring in many instances. Nurses who have frequent contact with women during the perinatal period are well positioned to provide screening and treatment for PPD. To implement the 2 part UK model (both screening and treatment), it is necessary to develop educational programs for staff and patients, and establish screening and treatment protocols as well as referral resources for those with such a need.