About 608,000 deaths from colorectal cancer are estimated worldwide, accounting for 8% of all cancer deaths, making it the fourth most common cause of death from cancer. As observed for incidence, mortality rates are lower in women than in men, except in the Caribbean. There is less variability in mortality rates worldwide (sixfold in men, fivefold in women), with the highest mortality rates in both sexes estimated in Central and Eastern Europe (20.3 per 100,000 for male, 12.1 per 100,000 for female), and the lowest in Middle Africa (3.5 and 2.7, respectively).