studies of amphetamine use during pregnancy have produced inconsistent result In a British study of 120 infant whose mother took any kind of prescribed dexamphetamine during the first trimester a significantly increased frequency of congenital anomalies was found In a case-control study of congenital heart disease Nora et al reported a positive association with dexamphetamine use during the first trimester In contrast the collaborative perinatal project demonstrated no increased frequency of congenital anomalies among 215 infant born to woman who took amphetamine sulfates or 89 infant born to woman who took methamphetamine during the first trimester Four cases of biliary atresia have been reported in association with fetal exposure to amphetamines in the second half of pregnancy Moreover Oro and Dixon in a study of cocaine,methamphetamine,and cocaine plus methamphetamine reported that both of these drugs were associated with an increased rate of both prematurity and intrauterine growth retardation , as well as altered neonatal behavioral patterns