The 24-h in vitro experiment confirmed the great penetration
potential of A-A-A in all skin compartments. After 6 h of
topical application, the removed tape strips from both in vitro and
in vivo experiments were analysed and the profile of diffusion of
A-A-A was determined, allowing also an in vitro/in vivo comparison.
The diffusion profile observed on the in vitro skin penetration
test is highly representative of the in vivo situation evaluated on
volunteers.
CONCLUSION: The combination of in vitro with in vivo data confirmed
that A-A-A has the capacity to diffuse through the skin after
topical application and reach the dermis as the targeted skin layer
for potential anti-ageing benefits.