Considering LOD from the perspective of the decision to include or disregard a peak for
integration purposes, stresses the importance of signal-to-noise ratio as a key parameter
governing peak detection. Defining LOD as 3.3 x noise creates a detection limit, which can
serve as a universal property of methods applicable to all analytes and different instruments
(because sensitivity factor has been disregarded in this form of the equation). LOD
expressed in this format is a dynamic property due to the dependency on the type of
instrument, status of the instrument, and quality of the consumables. LOD determined this
way will be expressed in units of peak height, e.g. mV or mAU.