The present work has compared the juice processing using the conventional thermal treatment with ultrasound along with the combination of ultrasound and UV irradiations. The analysis for the microbial content revealed that there is no significant difference between the thermal and non thermal treatments and the desired FDA log reduction could be obtained after optimization of the ultrasound parameters. The nutrient quality of food is of utmost importance as it may contribute significantly for health benefits of the product and may lead to acceptance or rejection of the product. The work presented here confirmed that it is possible to produce fruit and vegetable juices with excellent nutritional properties using ultrasound treatment as compared to the thermal sterilization method. Nutrient analysis of the ultrasound treated juice showed that the samples were at par with the fresh juice. The results strongly suggest that ultrasound technology has a significant potential for application in food industry. The use of combination approach as presented in this work also allows using the different irradiations in optimum mode so as to keep a balance between the microbial safety and the nutrient contents. Ultrasound treated juice sample might be the best option for consumers preferring health benefits from their food along with taste and goodness though the shelf life of this type of process juiced will be lower. The present work has provided an understanding about the possible better acceptability of sonicated juices and also indicated ways that the product could be adapted to consumer health benefits. Overall, it has been shown in this study that the non-thermal techniques could be helpful for food industry to produce fruit juice with high nutrient quality and paving the way for large scale commercialization of the technology as established from the scale up studies.