The interaction of thiabendazole (Tbz) with hemoglobin (Hb) on epoxy-functionalized iron oxide nanoparticles
was presented in this study. The binding capacity of Tbz was determined by measuring at an excitation wavelength
of 299 nm using fluorescence spectroscopy. The thermodynamic parameters of the Hb–Tbz interaction
were calculated from Stern–Volmer and van't Hoff equations. The values of enthalpy change, ΔH, and entropy
change, ΔS, were found to be 0.20 kJ mol−1 and 0.70 J mol−1 K−1
, respectively, which indicates that the hydrophilic
interaction plays a main role in the binding process. The interaction ability was confirmed by Fourier transform
infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). Also, the thermal behavior of the
Hb–Tbz interaction on functionalized iron oxide nanoparticles was studied by using the thermogravimetric analysis
(TGA) technique in the temperature range of 25–950 °C, and then the kinetic parameters for the thermal decomposition
were determined using the Horowitz–Metzger method.